Title : Investigating the impact of community-based education on key malaria prevention indicators in endemic regions: A systematic and bibliometric analysis

Introduction: With its significant disease burden, particularly in endemic regions, malaria remains a major global public health challenge. Community-Based Education (CBE) is a key strategy for improving preventive behaviors. This research is designed to answer three fundamental questions: 1) What is the overall effectiveness of CBE on prevention indicators? 2) Is there a relationship between the "dose" of education and the magnitude of the response? 3) What is the certainty of the existing scientific evidence in this field?

Methods: This study is a systematic review and dose-response meta-analysis conducted according to a protocol registered in PROSPERO and following the PRISMA guidelines. A comprehensive search of international databases (PubMed, Scopus, Embase, Web of Science) and grey literature will be performed to identify randomized and non-randomized controlled trials. Study selection, data extraction, and risk of bias assessment (using RoB 2 and ROBINS-I tools) will be carried out by two independent researchers. Reporting quality will be assessed using the CONSORT 2017 checklist. Statistical analyses will include meta-analysis with a random-effects model, dose-response analysis using regression models, and heterogeneity assessment with the I² statistic. The certainty of evidence for each outcome will be evaluated using the GRADE framework.

Findings: Expected results include an estimation of the overall effect size of CBE on improving malaria prevention Knowledge, Attitude, and Practice (KAP), such as insecticide-treated net (ITN) use and acceptance of indoor residual spraying (IRS). For instance, results similar to the study by Abamecha et al. (2020), which reported a 39% increase in ITN use following a school-based intervention, are anticipated. Furthermore, the quantitative relationship between the "dose" of education (e.g., number of sessions or duration) and the level of improvement in these indicators will be modeled. However, it is predicted that the reporting of "dose" in studies will be highly inconsistent, ranging from detailed reports to mentioning dose as a limitation or not reporting it at all.

Conclusion: This review will provide documented evidence for health policymakers and malaria control program implementers to optimize educational interventions. By identifying research gaps, particularly the urgent need for standardization in reporting intervention "dose," this study will define the path for future research to increase the efficiency of malaria control strategies. © 2025 Published by Public Knowledge Project (PKP).

Mohammad Hossein Delshad holds multiple degrees in public health, health promotion, medical education, and health policy, complemented by post-doctoral specialization. He has over 19 years of professional experience across teaching, health program coordination, research, and editorial roles in scientific journals. His work involves numerous leadership positions, including head of research centers, university committees, and social health projects. He has published 200 scientific articles, authored 12 books, and participated in over 79 research projects. His active participation in national and international scientific associations, including editorial boards and research networks, underscores his global engagement. Delshad has developed innovative health startup ideas, earning recognition through awards and startup competitions. He has contributed significantly to university development, strategic planning, and health promotion initiatives, especially during the COVID-19 pandemic.